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DNA carries organisms' genomes and also determines their vital processes. The ability to artificially alter DNA opens the way to both new scientific understanding and new treatment methods for various illnesses. In the early 1980s, Mario Capecchi discovered that sections of DNA that had been inserted into the cell nuclei of mammals could be incorporated into the cell's genome. In 1986, Mario Capecchi and Oliver Smithies successfully achieved specific modifications in the genomes of mice. By inactivating specific genes, their functions could be determined.